Characterization of pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis: implications for the clinical efficacy of nucleoside analogues

Characterization of pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis: implications for the clinical efficacy of nucleoside analogues.

In the present paper we demonstrate that the cytostatic and antiviral activity of pyrimidine nucleoside analogues is markedly decreased by a Mycoplasma hyorhinis infection and show that the phosphorolytic activity of the mycoplasmas is responsible for this. Since mycoplasmas are (i) an important cause of secondary infections in immunocompromised (e.g. HIV infected) patients and (ii) known to pr...

Mycoplasma hyorhinis-encoded purine nucleoside phosphorylase: kinetic properties and its effect on the cytostatic potential of purine-based anticancer drugs.

A mycoplasma-encoded purine nucleoside phosphorylase (designated PNPHyor) has been cloned and characterized for the first time. Efficient phosphorolysis of natural 6-oxopurine and 6-aminopurine nucleosides was observed, with adenosine the preferred natural substrate (Km = 61 µM). Several cytostatic purine nucleoside analogs proved to be susceptible to PNPHyor-mediated phosphorolysis, and a mark...

study of cohesive devices in the textbook of english for the students of apsychology by rastegarpour

this study investigates the cohesive devices used in the textbook of english for the students of psychology. the research questions and hypotheses in the present study are based on what frequency and distribution of grammatical and lexical cohesive devices are. then, to answer the questions all grammatical and lexical cohesive devices in reading comprehension passages from 6 units of 21units th...

Chemical Synthesis of Nucleoside Analogues Chemical Synthesis of Nucleoside Analogues

Antiviral Activity of 5-substituted Pyrimidine Nucleoside Analogues

From a large series of 5—substituted 1—(2—deoxy——D—ribofuranosyl)—ura— cil (dUrd) , 1—(2—deoxy——D—ribofuranosyl)—cytosine (dCyd) and 1—(—D—arabinofurano— syl)—uracil (araU) analogues that have been evaluated for their antiviral proper— ties, the (E)—5—(2—bromovinyl)derivatives emerged as the most potent and most selec— tive antiherpes agents. (E)—5—(2—Bromovinyl)—dUrd (BVDU) and its congeners, ...